Article
ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p.
Molecular biology of the cell - 1 Aug 2005
Miller Elizabeth A, Liu Yiting, Barlowe Charles, Schekman Randy
Abstract excerpt
Selective cargo capture into ER-derived vesicles is driven by the Sec24p subunit of the COPII coat, which contains at least three independent cargo-binding sites. One of these, the "A-site," interacts with a NPF motif found on the SNARE, Sed5p. We have characterized the Sec24p-Sed5p interaction t...
Topics
- Biological Transport
- COP-Coated Vesicles
- Cell Proliferation
- Endoplasmic Reticulum
- Golgi Apparatus
- Membrane Proteins
- Mutation
- Phenotype
- Qa-SNARE Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins