Article
Analysis of SNP profiles in patients with major depressive disorder.
The international journal of neuropsychopharmacology - 1 Apr 2006
Kõks Sulev, Nikopensius Tiit, Koido Kati, Maron Eduard, Altmäe Signe, Heinaste Evelin, Vabrit Kristel, Tammekivi Veronika, Hallast Pille, Kurg Ants, Shlik Jakov, Vasar Veiko, Metspalu Andres, Vasar Eero
Abstract excerpt
The present study focused on 91 single-nucleotide polymorphisms (SNPs) in 21 candidate genes to find associations with major depressive disorder (MDD). In total, 160 healthy controls and 177 patients with MDD were studied. We applied arrayed primer extension (APEX) based genotyping technology followed by association and haplotype analysis. SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally significant...
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