Article
Aberrant TP53 protein accumulation in the neuronal component of ganglioglioma.
Journal of neuro-oncology - 1 Apr 2005
Fukushima Takao, Katayama Yoichi, Watanabe Takao, Yoshino Atsuo, Komine Chiaki, Yokoyama Takakazu
Abstract excerpt
Gangliogliomas are characterized by their different phenotypic composition of ganglion cells and glial cells. In contrast to the glial cells that are capable of mitotic activity, the ganglion cells are generally considered to lack a neoplastic nature. The authors report here the first unequivocal case of a ganglioglioma harboring aberrant TP53 product that was expressed predominantly in the neuronal component....
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