Article
Determination of the minimal distance between the matrix and transmembrane domains of the large hepatitis B virus envelope protein.
Journal of virology - 1 Jun 2005
Kluge Britta, Schläger Michaela, Pairan Alexander, Bruss Volker
Abstract excerpt
The cytosolic matrix domain (MD) located between amino acids (aa) 103 and 124 of the large hepatitis B virus envelope protein L is essential for virion formation. We reduced the distance between MD and the transmembrane domain (TD; aa 254 to 272) by deletions starting at aa 132. Six mutants with deletions of up to aa 234 were wild type, and four mutants with slightly larger deletions were blocked with respect to...
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