Article
Development of a transgenic mouse model susceptible to human coronavirus 229E.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2005
Lassnig Caroline, Sanchez Carlos M, Egerbacher Monika, Walter Ingrid, Majer Susanne, Kolbe Thomas, Pallares Pilar, Enjuanes Luis, Müller Mathias
Abstract excerpt
Human coronavirus (HCoV) 229E is a group 1 coronavirus and is specific to humans. So far, no animal model is available to study the pathogenesis of infection by HCoV-229E. We show here that the expression of aminopeptidase N (APN, also termed CD13), the receptor for HCoV-229E, is required but not sufficient to confer susceptibility in vivo. HCoV-229E infection was facilitated by crossing APN transgenic mice into...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.