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Article

Germline niche transplantation restores fertility in infertile mice

26 May 2005

Abstract excerpt

BACKGROUND: Stem cells interact closely with their microenvironment or niche, and abnormalities in niche compromise the self-renewing tissue. In testis, for example, Sertoli cells interact with germ cells, and defects in Sertoli cells compromises spermatogenesis, leading to male infertility. However, it has not been possible to restore spermatogenesis from endogenous stem cells in infertile testis with...

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PMID: 15919776
DOI: 10.1093/humrep/dei096

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