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Sertoli Cells Dictate Spermatogonial Stem Cell Niches in the Mouse Testis

17 Nov 2010

Abstract excerpt

Sustained spermatogenesis in adult males relies on the activity of spermatogonial stem cells (SSCs). In general, tissue-specific stem cell populations such as SSCs are influenced by contributions of support cells that form niche microenvironments. Previous studies have provided indirect evidence that several somatic cell populations and the interstitial vasculature influence SSC functions, but an individual...

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PMID: 21084712
DOI: 10.1095/biolreprod.110.087320

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