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Article

GATA1 as a new target to detect minimal residual disease in both transient leukemia and megakaryoblastic leukemia of Down syndrome.

Leukemia research - 1 Nov 2005

Pine Sharon R, Guo Qianxu, Yin Changhong, Jayabose Somasundaram, Levendoglu-Tugal Oya, Ozkaynak M Fevzi, Sandoval Claudio

Abstract excerpt

Acquired mutations in exon 2 of the GATA1 gene are detected in most Down syndrome (DS) patients with transient leukemia (TL) and acute megakaryoblastic leukemia (AMKL). We sought to determine if GATA1 mutations can be utilized as markers for minimal residual disease (MRD). GATA1 mutations were sc...

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Share to Chromosomes, Human, Pair 21
Share to Cloning, Molecular
Share to Down Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA1 Transcription Factor

Share to Leukemia

Share to Leukemia, Megakaryoblastic, Acute

Share to Neoplasm, Residual

Share to Remission Induction

Source

Identifiers

PMID: 15916804
DOI: 10.1016/j.leukres.2005.04.007

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15916804-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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