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Pooling samples within microarray studies: a comparative analysis of rat liver transcription response to prototypical toxicants.

Physiological genomics - 11 Aug 2005

Jolly Robert A, Goldstein Keith M, Wei Tao, Gao Hong, Chen Peining, Huang Shuguang, Colet Jean-Marie, Ryan Timothy P, Thomas Craig E, Estrem Shawn T

Abstract excerpt

Combining or pooling individual samples when carrying out transcript profiling using microarrays is a fairly common means to reduce both the cost and complexity of data analysis. However, pooling does not allow for statistical comparison of changes between samples and can result in a loss of information. Because a rigorous comparison of the identified expression changes from the two approaches has not been...

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PMID: 15914576
DOI: 10.1152/physiolgenomics.00260.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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