Chromosome analysis in childhood cancer survivors and their offspring--no evidence for radiotherapy-induced persistent genomic instability.

doi:10.1016/j.mrgentox.2005.03.007

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Chromosome analysis in childhood cancer survivors and their offspring--no evidence for radiotherapy-induced persistent genomic instability.

Mutation research - 6 Jun 2005

Tawn E Janet, Whitehouse Caroline A, Winther Jeanette F, Curwen Gillian B, Rees Gwen S, Stovall Marilyn, Olsen Jørgen H, Guldberg Per, Rechnitzer Catherine, Schrøder Henrik, Boice John D

Abstract excerpt

Suggestions that the induction of genomic instability could play a role in radiation-induced carcinogenesis and heritable disease prompted the investigation of chromosome instability in relation to radiotherapy for childhood cancer. Chromosome analysis of peripheral blood lymphocytes at their first in vitro division was undertaken on 25 adult survivors of childhood cancer treated with radiation, 26 partners who...

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Chromosome analysis in childhood cancer survivors and their offspring--no evidence for radiotherapy-induced persistent genomic instability.

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