Article
Cooperation between alteration of DNA gyrase genes and over-expression of MexB and MexX confers high-level fluoroquinolone resistance in Pseudomonas aeruginosa strains isolated from a patient who received a liver transplant followed by treatment with fluoroquinolones.
Microbiology and immunology - 1 Jan 2005
Niga Toshiyuki, Ito Hideaki, Oyamada Yoshihiro, Yamagishi Jun-Ichi, Kadono Manami, Nishino Takeshi, Gotoh Naomasa, Inoue Matsuhisa
Abstract excerpt
Clinical isolates of highly fluoroquinolone-resistant Pseudomonas aeruginosa had a mutation in either A or B subunit of DNA gyrase and over-expressed MexB and MexX, the efflux system proteins. Introduction of wild-type gyrase genes of Escherichia coli into the isolates made them as fluoroquinolonesusceptible as the moderately fluoroquinolone-resistant strains that only over-expressed efflux system proteins. These...
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