Allele frequencies and the r2 measure of linkage disequilibrium: impact on design and interpretation of association studies.

Abstract excerpt

The design and interpretation of genetic association studies depends on the relationship between the genotyped variants and the underlying functional variant, often parameterized as the squared correlation or r(2) measure of linkage disequilibrium between two loci. While it has long been recognized that placing a constraint on ther(2) between two loci also places a constraint on the difference in frequencies...

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