Article
Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X region.
Psychiatric genetics - 1 Jun 2005
Vincent John B, Melmer Georg, Bolton Patrick F, Hodgkinson Steve, Holmes Debbie, Curtis David, Gurling Hugh M D
Abstract excerpt
The higher prevalence of autism in males than in females suggests the possible involvement of the X chromosome. To test the hypothesis that there are mutations increasing susceptibility to autism on the X chromosome, and in particular the distal portion of the long arm that encompasses the FMRI and MECP2 loci, a genetic linkage study was performed. Twenty-two fragile X-negative families multiplex for autism and...
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