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Article

Linkage analysis in Rett syndrome families suggests that there may be a critical region at Xq28.

Journal of medical genetics - 1 Dec 1998

Webb T, Clarke A, Hanefeld F, Pereira J L, Rosenbloom L, Woods C G

Abstract excerpt

A whole X chromosome study of families in which Rett syndrome had been diagnosed in more than one member indicated that the region between Xq27 and Xqter was the most likely region to harbour a gene which may be involved in the aetiology of the disease. Further, more detailed studies of Xq28 detected weak linkage and a higher than expected sharing of maternally inherited alleles. It is suggested that there may be...

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Identifiers

PMID: 9863596
DOI: 10.1136/jmg.35.12.997
PMCID: PMC1051511

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