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TReP-132 Controls Cell Proliferation by Regulating the Expression of the Cyclin-Dependent Kinase Inhibitors p21 <sup>WAF1/Cip1</sup> and p27 <sup>Kip1</sup>

16 May 2005

Abstract excerpt

The transcriptional regulating protein of 132 kDa (TReP-132) has been identified in steroidogenic tissues, where it acts as a coactivator of steroidogenic factor 1 (SF-1). We show here that TReP-132 plays a role in the control of cell proliferation. In human HeLa cells, TReP-132 knockdown by using small interfering RNA resulted in increased G(1)-->S cell cycle progression. The growth-inhibitory effects of...

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PMID: 15899840
DOI: 10.1128/mcb.25.11.4335-4348.2005

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