Article
An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation.
The Biochemical journal - 1 Apr 2015
Degese Maria Sol, Tanos Tamara, Naipauer Julian, Gingerich Tim, Chiappe Diego, Echeverria Pablo, LaMarre Jonathan, Gutkind J Silvio, Coso Omar A
Abstract excerpt
Mitogen-activated protein kinase (MAPK) pathways constitute key regulatory elements linking extracellular stimuli to nuclear gene expression. Immediate-early responsive genes (IEGs) of the activator protein 1 (AP-1) family, such as fos, achieve peak expression levels shortly after cells are stimulated with growth factors and sharply decrease thereafter. Several AU-rich binding proteins (AUBPs), including HuR...
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