Article
Phenotypic modifications of vascular smooth muscle cells could be responsible for vascular hyporeactivity to contracting agent in mechanically injured rat carotid artery.
Atherosclerosis - 1 Dec 2005
Popolo A, Marzocco S, Nasti C, Lippolis L, di Villa Bianca R d'Emmanuele, Sorrentino R, Autore G, Pinto A
Abstract excerpt
Vascular smooth muscle cells (VSMCs) that accumulate in neointima after angioplastic injury show different phenotypic characteristics from those of medial layer and an impaired reactivity to contracting agents. The aim of the study was to correlate the vascular hyporesponsiveness to the changes in intracellular calcium concentration [Ca(2+)](i) and the expression of proteins necessary for its utilization in...
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