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Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice.

Genes, chromosomes & cancer - 1 Sept 2005

Kalitsis Paul, Fowler Kerry J, Griffiths Belinda, Earle Elizabeth, Chow C W, Jamsen Kris, Choo K H Andy

Abstract excerpt

Mitotic spindle checkpoint proteins have been shown to play a crucial role in the accurate segregation of chromosomes during cell division. Bub3 is a member of a group of mitotic checkpoint proteins that are essential for this process. To investigate the role of Bub3 in chromosome segregation and cancer development, we analyzed haploinsufficient cells in mice. Heterozygous Bub3 embryonic fibroblasts displayed...

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Identifiers

PMID: 15898111
DOI: 10.1002/gcc.20215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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