Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice.

doi:10.1002/gcc.20215

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Article

Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice.

Genes, chromosomes & cancer - 1 Sept 2005

Kalitsis Paul, Fowler Kerry J, Griffiths Belinda, Earle Elizabeth, Chow C W, Jamsen Kris, Choo K H Andy

Abstract excerpt

Mitotic spindle checkpoint proteins have been shown to play a crucial role in the accurate segregation of chromosomes during cell division. Bub3 is a member of a group of mitotic checkpoint proteins that are essential for this process. To investigate the role of Bub3 in chromosome segregation and...

Topics

Aneuploidy
Animals
Base Sequence
Cell Cycle Proteins
Chromosomal Instability
Chromosomal Proteins, Non-Histone
Chromosome Mapping
DNA Primers
Embryo, Mammalian
Fibroblasts
Genetic Predisposition to Disease
Genotype
Heterozygote
Mice
Mice, Inbred Strains
Neoplasms
Poly-ADP-Ribose Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 15898111
DOI: 10.1002/gcc.20215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15898111-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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