Article
Integration of high-risk human papillomavirus DNA correlates with HLA genotype aberration and reduced HLA class I molecule expression in human cervical carcinoma.
Clinical immunology (Orlando, Fla.) - 1 Jun 2005
Sheu Bor-Ching, Chiou Shin-Heng, Chang Wen-Chun, Chow Song-Nan, Lin Ho-Hsiung, Chen Ruey-Jien, Huang Su-Cheng, Ho Hong-Nerng, Hsu Su-Ming
Abstract excerpt
In human cervical cancer (CC), local immunity against this human papilloma virus (HPV)-associated neoplasia has been signified. To stratify the possibility of HPV integration on HLA mutations, we measured the genotypic and phenotypic integrity of all available HLA class I loci in 30 cases of CC. Paired normal and cancer genomic DNA was analyzed with DNA typing trays, including 57 subtypes of HLA-A, 120 subtypes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
