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Human Herpesvirus 7 Open Reading Frames U12 and U51 Encode Functional β-Chemokine Receptors

12 May 2005

Abstract excerpt

Human herpesvirus 7 (HHV-7), which belongs to the betaherpesvirus subfamily and infects mainly CD4+ T cells in vitro, infects children during infancy. HHV-7 contains two genes, U12 and U51, that encode putative homologs of cellular G-protein-coupled receptors. To analyze the biological function of the U12 and U51 genes, we cloned these genes and expressed the proteins in cells. U12 and U51 encoded functional...

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Identifiers

PMID: 15890946
DOI: 10.1128/jvi.79.11.7068-7076.2005

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