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Article

RANTES Binding and Down-Regulation by a Novel Human Herpesvirus-6 β Chemokine Receptor

1 Mar 2000

Abstract excerpt

The human herpesvirus 6 (HHV-6) U51 gene defines a new family of betaherpesvirus-specific genes encoding multiple transmembrane glycoproteins with similarity to G protein-coupled receptors, in particular, human chemokine receptors. These are distinct from the HHV-6 U12 and HCMV US28 family. In vitro transcription and translation as well as transient cellular expression of U51 showed properties of a multiple...

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PMID: 10679075
DOI: 10.4049/jimmunol.164.5.2396

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