Article
Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using, primary human immunodeficiency virus type 1 strains.
Journal of virology - 1 Jun 2005
Lusso Paolo, Earl Patricia L, Sironi Francesca, Santoro Fabio, Ripamonti Chiara, Scarlatti Gabriella, Longhi Renato, Berger Edward A, Burastero Samuele E
Abstract excerpt
The external subunit of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env), gp120, contains conserved regions that mediate sequential interactions with two cellular receptor molecules, CD4 and a chemokine receptor, most commonly CCR5 or CXCR4. However, antibody accessibility to such regions is hindered by diverse protective mechanisms, including shielding by variable loops, conformational...
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