Article
FcgammaRIIIb and complement component C7 codeficiency in a patient with recurrence of fulminant meningococcal septic shock.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2005
Debard Anne-Lise, Lamy Brigitte, Monneret Guillaume, Mira Jean-Paul, Pachot Alexandre, Kleijer Marion, Aillaud Marie-Françoise, Boibieux André, Bienvenu Jacques, Carret Gérard, Fournier Gérard, Bohé Julien
Abstract excerpt
Individuals with deficiencies of the late components of complement exhibit a susceptibility to the recurrence of meningococcal disease with a usually mild clinical presentation. We report the recurrence of fulminant meningococcal disease in a complement component C7-deficient patient. We found a total deficiency of FcgammaRIIIb on neutrophils, which could partially explain the unusually severe clinical presentation.
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