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Article

Molecular and genealogical characterization of the R1443X BRCA1 mutation in high-risk French-Canadian breast/ovarian cancer families.

Human genetics - 1 Jul 2005

Vézina Hélène, Durocher Francine, Dumont Martine, Houde Louis, Szabo Csilla, Tranchant Martine, Chiquette Jocelyne, Plante Marie, Laframboise Rachel, Lépine Jean, Nevanlinna Heli, Stoppa-Lyonnet Dominique, Goldgar David, Bridge Peter, Simard Jacques

Abstract excerpt

The Quebec population contains about six-million French Canadians, descended from the French settlers who colonized "Nouvelle-France" between 1608 and 1765. Although the relative genetic contribution of each of these founders is highly variable, altogether they account for the major part of the contemporary French-Canadian gene pool. This study was designed to analyze the role of this founder effect in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15883839
DOI: 10.1007/s00439-005-1297-9

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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