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BRCA1 testing in breast and/or ovarian cancer families from northeastern France identifies two common mutations with a founder effect.

Familial cancer - 1 Jan 2004

Muller Danièle, Bonaiti-Pellié Catherine, Abecassis Joseph, Stoppa-Lyonnet Dominique, Fricker Jean-Pierre

Abstract excerpt

OBJECTIVE: The purpose of this study was to determine whether two mutations detected frequently in a population of breast and/or ovarian cancer families originating from the northeastern part of France could be due to a founder effect. METHODS: 83 index cases of families ascertained to have a familial breast and/or ovarian cancer history, were screened for mutations in all coding exons of the BRCA1 gene, using...

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Source

Identifiers

PMID: 15131401
DOI: 10.1023/B:FAME.0000026819.44213.df

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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