Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates.

International journal of antimicrobial agents - 1 Jun 2005

Ruiz Joaquim, Moreno Asunción, Jimenez de Anta M Teresa, Vila Jordi

Abstract excerpt

The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aza Compounds
Share to Campylobacter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Gyrase

Share to Drug Resistance, Bacterial

Share to Fluoroquinolones

Share to Moxifloxacin

Share to Quinolines

Source

Identifiers

PMID: 15876526
DOI: 10.1016/j.ijantimicag.2004.10.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates.PMID 15876526Read ↗

Single or double mutational alterations of gyrA associated with fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli.Semantic proximity Read ↗

Identification of the main quinolone resistance determinant in Campylobacter jejuni and Campylobacter coli by MAMA-DEG PCR.Semantic proximity Read ↗

Increased resistance to quinolones in Campylobacter jejuni: a genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates.Semantic proximity Read ↗

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.Semantic proximity Read ↗

Characterization of gyrA mutations associated with fluoroquinolone resistance in Campylobacter coli by DNA sequence analysis and MAMA PCR.Semantic proximity Read ↗

Quinolone resistance and Campylobacter spp.Semantic proximity Read ↗

Ribosomal Mutations as the Main Cause of Macrolide Resistance in Campylobacter jejuni and Campylobacter coliSemantic proximity Read ↗

Formation of the Resistance of Campylobacter jejuni to Macrolide Antibiotics.Semantic proximity Read ↗

Molecular mechanisms of quinolone, macrolide, and tetracycline resistance among Campylobacter isolates from initial stages of broiler production.Semantic proximity Read ↗

Impact of mutations in DNA gyrase genes on quinolone resistance in Campylobacter jejuni.Semantic proximity Read ↗

Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli.Semantic proximity Read ↗

Single and double mutations in gyrA but not in gyrB are associated with low- and high-level fluoroquinolone resistance in Helicobacter pylori.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.