Article
Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele.
Journal of acquired immune deficiency syndromes (1999) - 15 Dec 2005
Vidal Francesc, Viladés Consuelo, Domingo Pere, Broch Montserrat, Pedrol Enric, Dalmau David, Knobel Hernando, Peraire Joaquim, Gutiérrez Cristina, Sambeat Ma Antònia, Fontanet Angels, Deig Elisabeth, Cairó Mireia, Montero Milagros, Richart Cristóbal, Mallal Simon
Abstract excerpt
BACKGROUND AND OBJECTIVES: The influence of the polymorphisms of the CX3CR1 chemokine receptor gene on the natural history of HIV-1 infection is controversial. This study aimed to determine whether functionally active CX3CR1 genetic variants are associated with long-term nonprogressive infection of >15 years in HIV-1-infected Spanish patients. PATIENTS AND METHODS: Two single-nucleotide polymorphisms, V249I (G >...
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