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Article

Induction of syngeneic cytotoxic T lymphocytes against a B cell tumor. I. Role of idiotypic immunoglobulin.

Cellular immunology - 1 Jun 1992

Chakrabarti D, Ghosh S K

Abstract excerpt

In previous studies we showed that idiotypic determinants of a B cell hybrid, 2C3, was involved in the generation of idiotype (Id)-specific noncytolytic CD4+ effector T cells that suppressed the Ig expression of wild type 2C3 tumor. In the present investigation we report that Id+ Ig associated with 2C3 was also capable of eliciting syngeneic cytotoxic T lymphocytes (CTL) when mice were hyperimmunized with...

Topics

Animals
Antibodies, Monoclonal
B-Lymphocytes
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Hybridomas
Immunization, Passive
Immunoglobulin Idiotypes
Lymphocyte Activation
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

T-Lymphocytes

T-Lymphocytes, Cytotoxic

Tumor Cells, Cultured

Source

Identifiers

PMID: 1586959
DOI: 10.1016/0008-8749(92)90268-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1586959-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Induction of syngeneic cytotoxic T lymphocytes against a B cell tumor. I. Role of idiotypic immunoglobulin.PMID 1586959Read ↗

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