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Why females live longer than males? Importance of the upregulation of longevity‐associated genes by oestrogenic compounds

14 Apr 2005

Abstract excerpt

Females live longer than males in many mammalian species, including humans. Mitochondria from females produce approximately half the amount of H(2)O(2) than males. We have found that females behave as double transgenics overexpressing both superoxide dismutase and glutathione peroxidase. This is due to oestrogens that act by binding to the estrogen receptors and subsequently activating the mitogen activated...

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Share to Antioxidant Activity and Oxidative Stress
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PMID: 15862287
DOI: 10.1016/j.febslet.2005.03.090

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