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Why Females Live Longer Than Males: Control of Longevity by Sex Hormones

8 Jun 2005

Abstract excerpt

Females live longer than males in many species, including humans. We have traced a possible explanation for this phenomenon to the beneficial action of estrogens, which bind to estrogen receptors and increase the expression of longevity-associated genes, including those encoding the antioxidant enzymes superoxide dismutase and glutathione peroxidase. As a result, mitochondria from females produce fewer reactive...

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Share to Antioxidant Activity and Oxidative Stress
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PMID: 15944465
DOI: 10.1126/sageke.2005.23.pe17

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