Article
Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer.
Pharmacogenetics and genomics - 1 Mar 2005
Liu Zhensheng, Calderon John I, Zhang Zhengdong, Sturgis Erich M, Spitz Margaret R, Wei Qingyi
Abstract excerpt
Vitamin D has potent anti-tumour properties. Calcitriol [1,25(OH)2D3], the hormonal derivative of vitamin D3, is an antiproliferative and prodifferentiation factor for several cell types, including human squamous cells of the head and neck. Several polymorphisms of the vitamin D receptor (VDR) gene have been described, including a FokI restriction fragment-length polymorphism (RFLP) in exon 2 and an adjacent TaqI...
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