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Article

Limited development and progression of resistance of HIV-1 to the nucleoside analogue reverse transcriptase inhibitor lamivudine in human primary macrophages.

The Journal of antimicrobial chemotherapy - 1 Jun 2005

Aquaro Stefano, Svicher Valentina, Ceccherini-Silberstein Francesca, Cenci Alessandra, Marcuccilli Fabbio, Giannella Sara, Marcon Luisa, Caliò Raffaele, Balzarini Jan, Perno Carlo-Federico

Abstract excerpt

OBJECTIVES: The aim of this study was to investigate the development and progression of phenotypic resistance to the HIV-1-reverse transcriptase (RT) inhibitor lamivudine, and genotypic variations of HIV-1-RT occurring under lamivudine treatment in HIV-1-infected human primary monocytes-macrophages (M/M). METHODS: Cellular passages in the presence of lamivudine were performed every 2 weeks by transferring...

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PMID: 15845785
DOI: 10.1093/jac/dki104

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CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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