Article
Small cerebral vessel disease in familial amyloid and non-amyloid angiopathies: FAD-PS-1 (P117L) mutation and CADASIL. Immunohistochemical and ultrastructural studies.
Folia neuropathologica - 1 Jan 2007
Szpak Grazyna M, Lewandowska Eliza, Wierzba-Bobrowicz Teresa, Bertrand Ewa, Pasennik Elzbieta, Mendel Tadeusz, Stepień Tomasz, Leszczyńska Anna, Rafałowska Janina
Abstract excerpt
Three patients (of two unrelated Polish families) with early-adult onset dementia were subjects of the study. Two cases, previously diagnosed as familial Alzheimer's disease (FAD) with cerebral amyloid angiopathy (CAA), were confirmed by genetic and neuropathological studies, and one case of CADASIL was ultrastructurally confirmed by the presence of vascular granular osmiophilic material. Now the brain autopsy...
Topics
- Actins
- Adult
- Alzheimer Disease
- Blood Vessels
- Brain
- CADASIL
- Cerebral Amyloid Angiopathy, Familial
- Collagen Type III
- Collagen Type IV
- Humans