Article
Drosophila melanogaster S2 cells: a model system to study Chlamydia interaction with host cells
9 Mar 2005
Abstract excerpt
Chlamydia spp. are major causes of important human diseases, but dissecting the host-pathogen interactions has been hampered by the lack of bacterial genetics and the difficulty in carrying out forward genetic screens in mammalian hosts. RNA interference (RNAi)-based methodologies for gene inactivation can now be easily carried out in genetically tractable model hosts, such as Drosophila melanogaster, and offer a...
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