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Article

Enhancing rAAV vector expression in the lung

19 Apr 2005

Abstract excerpt

Despite favorable DNA transfer efficiency, gene expression from recombinant adeno-associated virus (rAAV2) vectors in the lung has been variable in the context of cystic fibrosis (CF) gene therapy. This is due, in part, to the large size of the CF transmembrane regulator (CFTR)-coding sequence which necessitates the use of compact endogenous promoter elements versus stronger exogenous promoters. We evaluated the...

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PMID: 15838934
DOI: 10.1002/jgm.759

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