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Article

Gene Expression from Adeno-associated Virus Vectors in Airway Epithelial Cells

1 Sept 1992

Abstract excerpt

Lung diseases such as cystic fibrosis (CF) might be treated by gene therapy using viral vectors delivered to the airway. One potential vector is the defective human parvovirus, adeno-associated virus (AAV). We examined the AAV p5 transcription promoter for gene expression in immortalized cell lines derived from the airway (IB3-1) or pancreas (CFPAC-1) of CF patients. AAV vectors expressing the prokaryotic genes...

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PMID: 1325813
DOI: 10.1165/ajrcmb/7.3.349

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