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Recent Developments in Recombinant AAV-Mediated Gene Therapy for Lung Diseases

1 Jun 2005

Abstract excerpt

Recent studies have shed light on a number of important obstacles to safe and effective gene transfer to the respiratory tract with recombinant AAV vectors. Among these are blocks at the level of receptor binding and internalizations, evasion of proteasomal degradation, inefficiency of nuclear entry, and nuclear factors that inhibit the conversion of rAAV genomes into active double-stranded DNA form. Other...

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PMID: 15975013
DOI: 10.2174/1566523054064986

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