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Article

Basement membrane fragility underlies embryonic lethality in fukutin-null mice.

Neurobiology of disease - 1 Jan 2000

Kurahashi Hiroki, Taniguchi Mariko, Meno Chikara, Taniguchi Yoshihiro, Takeda Satoshi, Horie Masato, Otani Hiroki, Toda Tatsushi

Abstract excerpt

Fukuyama-type congenital muscular dystrophy (FCMD), associated with brain malformation due to defects in neuronal migration, is caused by mutations in fukutin. Several lines of evidence suggest that the fukutin protein plays a pivotal role in synthesis of O-mannosyl sugar moieties of alpha-dystroglycan, a cell surface laminin receptor. Here, through targeted disruption of the orthologous mouse fukutin gene, we...

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Source

Identifiers

PMID: 15837576
DOI: 10.1016/j.nbd.2004.12.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Basement membrane fragility underlies embryonic lethality in fukutin-null mice.PMID 15837576Read ↗

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Fukuyama‐type congenital muscular dystrophy (FCMD) and α‐dystroglycanopathySemantic proximity Read ↗

Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan.Semantic proximity Read ↗

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