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Article

Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy.

The Journal of clinical investigation - 1 Sept 2012

Beedle Aaron M, Turner Amy J, Saito Yoshiaki, Lueck John D, Foltz Steven J, Fortunato Marisa J, Nienaber Patricia M, Campbell Kevin P

Abstract excerpt

Dystroglycan is a transmembrane glycoprotein that links the extracellular basement membrane to cytoplasmic dystrophin. Disruption of the extensive carbohydrate structure normally present on α-dystroglycan causes an array of congenital and limb girdle muscular dystrophies known as dystroglycanopathies. The essential role of dystroglycan in development has hampered elucidation of the mechanisms underlying...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22922256
DOI: 10.1172/JCI63004
PMCID: PMC3428090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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