Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental defects in a zebrafish model for muscular dystrophies associated with the loss of fukutin-related protein (FKRP)

13 May 2008

Abstract excerpt

A number of muscular dystrophies are associated with the defective glycosylation of alpha-dystroglycan and many are now known to result from mutations in a number of genes encoding putative or known glycosyltransferases. These diseases include severe forms of congenital muscular dystrophy (CMD) such as Fukuyama type congenital muscular dystrophy (FCMD), Muscle-Eye-Brain disease (MEB) and Walker-Warburg syndrome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Muscle Physiology and Disorders
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18477595
DOI: 10.1093/brain/awn078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental defects in a zebrafish model for muscular dystrophies associated with the loss of fukutin-related protein (FKRP)PMID 18477595Read ↗

Basement membrane fragility underlies embryonic lethality in fukutin-null mice.Semantic proximity Read ↗

Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryosSemantic proximity Read ↗

Removal of pomt1 in zebrafish leads to loss of α-dystroglycan glycosylation and dystroglycanopathy phenotypes.Semantic proximity Read ↗

Mouse models of fukutin-related protein mutations show a wide range of disease phenotypes.Semantic proximity Read ↗

Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy.Semantic proximity Read ↗

Removal of <i>pomt1</i> in zebrafish leads to loss of α-dystroglycan glycosylation and dystroglycanopathy phenotypesSemantic proximity Read ↗

Fukutin-related protein alters the deposition of laminin in the eye and brain.Semantic proximity Read ↗

Adeno-associated virus-mediated overexpression of LARGE rescues α-dystroglycan function in dystrophic mice with mutations in the fukutin-related protein.Semantic proximity Read ↗

Fukuyama‐type congenital muscular dystrophy (FCMD) and α‐dystroglycanopathySemantic proximity Read ↗

Reduced expression of fukutin related protein in mice results in a model for fukutin related protein associated muscular dystrophies.Semantic proximity Read ↗

Prenatal muscle development in a mouse model for the secondary dystroglycanopathies.Semantic proximity Read ↗

Functional implications of Fkrp deficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.