Article
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Nature - 14 Apr 2005
Farmer Hannah, McCabe Nuala, Lord Christopher J, Tutt Andrew N J, Johnson Damian A, Richardson Tobias B, Santarosa Manuela, Dillon Krystyna J, Hickson Ian, Knights Charlotte, Martin Niall M B, Jackson Stephen P, Smith Graeme C M, Ashworth Alan
Abstract excerpt
BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous recombination, and mutations in these genes predispose to breast and other cancers. Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in base excision repair, a key pathway in the repair of DNA single-strand breaks. We show here that BRCA1 or BRCA2 dysfunction unexpectedly and profoundly sensitizes cells to the inhibition of...
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