Targeting the BRCA1/2 Tumor Suppressors

Abstract excerpt

The breast cancer susceptibility genes BRCA1 and BRCA2 are classic tumor suppressor genes that exhibit an autosomal dominant pattern of inheritance with high penetrance. BRCA carriers inherit one mutant BRCA allele and one wild-type allele; and the wild-type allele is invariably deleted or mutated within the tumor. These genes function as caretakers in the maintenance of genomic stability, in part, by...

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• BRCA gene mutations in cancer
• DNA Repair Mechanisms
• PARP inhibition in cancer therapy