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Article

Variation in transplacental transfer of tyrosine kinase inhibitors in the human perfused cotyledon model.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2015

Jovelet C, Seck A, Mir O, Simasotchi C, Broutin S, Goffinet F, Bidart J M, Paci A, Gil S

Abstract excerpt

BACKGROUND: The use of tyrosine kinase inhibitors (TKis) during pregnancy in humans remains rare, and little data are available on their transplacental passage. Erlotinib and gefitinib are the first-line targeted therapy in case of stage IV nonsmall-cell lung cancer with an EGFR-activating mutation. There are no data available regarding the comparative use of these TKis in pregnant patients. We aimed to compare...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25851627
DOI: 10.1093/annonc/mdv172

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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