Article
Gefitinib-Induced Cutaneous Toxicities in Brown Norway Rats Are Associated with Macrophage Infiltration.
Inflammation - 1 Dec 2020
Wan Liangqin, Wang Yalei, Tang Yibo, Tan Yan, He Fang, Zhang Yali, Yang Ke, Chen Ziwei, Song Chenchen, Gu Ruoxi, Zhang Ce, Wang Xu, Wei Peng, Liu Tonghua, Jiang Miao, Hua Qian
Abstract excerpt
Gefitinib (Iressa), is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), used in the targeted treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC). Skin toxicity is the major adverse effect observed in patients treated with EGFR-targeted TKIs such as gefitinib and erlotinib. To date, a corresponding skin animal model has not been established to address...
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