Article
Understanding differences between phylogenetic and pedigree-derived mtDNA mutation rate: a model using families from the Azores Islands (Portugal).
Molecular biology and evolution - 1 Jun 2005
Santos Cristina, Montiel Rafael, Sierra Blanca, Bettencourt Conceição, Fernandez Elisabet, Alvarez Luis, Lima Manuela, Abade Augusto, Aluja M Pilar
Abstract excerpt
We analyzed the control region of the mitochondrial DNA (mtDNA) from maternally related individuals originating from the Azores Islands (Portugal) in order to estimate the mutation rate of mtDNA and to gain insights into the process by which a new mutation arises and segregates into heteroplasmy. Length and/or point heteroplasmies were found at least in one individual of 72% of the studied families. Eleven new...
Topics
- Azores
- Biological Evolution
- Cloning, Molecular
- DNA Mutational Analysis
- DNA, Mitochondrial
- Evolution, Molecular
- Female
- Genetic Drift
- Humans
- Male
- Models, Genetic
- Models, Statistical
- Mutation