Article
High mitochondrial mutation rates estimated from deep-rooting Costa Rican pedigrees.
American journal of physical anthropology - 1 Jul 2012
Madrigal Lorena, Posthumously Loredana Castrì, Melendez-Obando Mauricio, Villegas-Palma Ramon, Barrantes Ramiro, Raventos Henrieta, Pereira Reynaldo, Luiselli Donata, Pettener Davide, Barbujani Guido
Abstract excerpt
Estimates of mutation rates for the noncoding hypervariable Region I (HVR-I) of mitochondrial DNA vary widely, depending on whether they are inferred from phylogenies (assuming that molecular evolution is clock-like) or directly from pedigrees. All pedigree-based studies so far were conducted on populations of European origin. In this article, we analyzed 19 deep-rooting pedigrees in a population of mixed origin...
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