Article
Origins of a mutation: population genetics of Machado-Joseph disease in the Azores (Portugal).
Human biology - 1 Dec 1998
Lima M, Mayer F M, Coutinho P, Abade A
Abstract excerpt
Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder of adult onset. In the islands of the Azores (Portugal), MJD reaches the highest prevalence reported worldwide. It has been postulated that it is highly represented in the Azorean population as a result of a founder...
Topics
- Adult
- Azores
- Chi-Square Distribution
- Child
- Demography
- Female
- Genealogy and Heraldry
- Genetics, Population
- History, 20th Century
- Humans
- Incidence
- Machado-Joseph Disease
- Male
- Mutation
- Pedigree
- Risk Factors
- White People