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Article

Detection of the BRAF V600E mutation in melanocytic lesions using the ligase detection reaction.

Journal of cutaneous pathology - 1 May 2005

Turner Daniel J, Zirvi Monib A, Barany Francis, Elenitsas Rosalie, Seykora John

Abstract excerpt

BACKGROUND: BRAF is a member of the RAF kinase family, and it promotes signaling through the RAS-MAP kinase signal transduction cascade. Research has shown that a majority of melanomas and nevi exhibit an activating V600E (T1799A) mutation in BRAF exon 15. Additional studies of BRAF have demonstrated that the T1799A mutation is absent in uveal melanomas and Spitz nevi. METHODS: The ligase detection reaction (LDR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15811117
DOI: 10.1111/j.0303-6987.2005.00338.x

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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