Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic role of interleukin-1beta gene and interleukin-1 receptor antagonist gene polymorphisms in patients with advanced gastric cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2005

Graziano Francesco, Ruzzo Annamaria, Santini Daniele, Humar Bostjan, Tonini Giuseppe, Catalano Vincenzo, Berardi Rossana, Pizzagalli Francesca, Arduini Federica, Bearzi Italo, Scartozzi Mario, Cascinu Stefano, Testa Enrica, Ficarelli Rita, Magnani Mauro

Abstract excerpt

PURPOSE: A high interleukin-1beta (IL-1B) and interleukin-1 receptor antagonist (IL-RN) ratio underlies an unfavorable proinflammatory status. Also, it seems to be involved in the mechanisms of cancer cachexia and tumor angiogenesis and metastasis. Two single nucleotide polymorphisms in IL-1B gene (IL-1B-511C/T,IL-1B-31T/C) and a variable number of tandem repeat polymorphisms in IL-RN gene (IL-1RNlong/2) enhance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Interleukin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Palliative Care

Share to Polymorphism, Genetic

Share to Prognosis

Share to Receptors, Interleukin-1

Share to Stomach Neoplasms

Share to Survival Analysis

Source

Identifiers

PMID: 15800325
DOI: 10.1200/JCO.2005.02.345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic role of interleukin-1beta gene and interleukin-1 receptor antagonist gene polymorphisms in patients with advanced gastric cancer.PMID 15800325Read ↗

The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1β.Semantic proximity Read ↗

Polymorphisms in interleukin-1B (IL-1B) and interleukin 1 receptor antagonist (IL-1RN) genes associate with gastric cancer risk in the Chinese population.Semantic proximity Read ↗

Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1beta cytokine in Korean patients with gastric cancer.Semantic proximity Read ↗

[The role of interleukin-1beta gene polymorphism in the gastric carcinogenesis].Semantic proximity Read ↗

Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis.Semantic proximity Read ↗

Variations in the interleukin-1 receptor antagonist gene impact on survival of patients with advanced colorectal cancer.Semantic proximity Read ↗

Effect of IL-1β and TNF-α polymorphisms on the prognosis and survival of gastric cancer patients.Semantic proximity Read ↗

Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China.Semantic proximity Read ↗

Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis.Semantic proximity Read ↗

Two variants of Interleukin-1B gene are associated with the decreased risk, clinical features, and better overall survival of colorectal cancer: a two-center case-control studySemantic proximity Read ↗

Association of IL-1beta gene polymorphism with cachexia from locally advanced gastric cancer.Semantic proximity Read ↗

CyclinD1 and interleukin-1 receptor antagonist polymorphisms are associated with prognosis in neoadjuvant-treated gastric carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.