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Article

Ductular reaction in hereditary hemochromatosis: The link between hepatocyte senescence and fibrosis progression

26 Aug 2013

Abstract excerpt

UNLABELLED: The development of portal fibrosis following the iron loading of hepatocytes is the first stage of fibrogenesis in hereditary hemochromatosis. In other chronic liver diseases it has been shown that a ductular reaction (DR) appears early, correlates with fibrosis progression, and is a consequence of activation of an alternative pathway of hepatocyte replication. This study was designed to investigate...

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PMID: 24037895
DOI: 10.1002/hep.26706

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